Abstract |
Solid tumors produced in mice by Ehrlich ascites cancer cells were completely regressed by treatment with the copolymer of polyriboinosinic acid-polyribocytidylic acid ( poly (I):(C)) when 200 microgram of this compound was intravenously injected 3 times a week for 3-4 weeks, starting 7-8 days after transplantation of the tumor. Although the first injection of poly (I):(C) caused hyporeactivity to re-induction of IFN, the subsequent 6 doses stimulated the formation of IFN at 3685 units/ml on average after each injection, strongly suggesting that IFN plays a role in the antitumoral effect of poly (I):(C).
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Authors | Y Nagano, S Takano |
Journal | Journal of interferon research
(J Interferon Res)
Vol. 2
Issue 1
Pg. 103-5
( 1982)
ISSN: 0197-8357 [Print] United States |
PMID | 6180096
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Carcinoma, Ehrlich Tumor
(metabolism)
- Dose-Response Relationship, Drug
- Injections, Intravenous
- Interferons
(biosynthesis)
- Male
- Mice
- Poly I-C
(administration & dosage, pharmacology)
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