A putative interferon induced in hamsters by poly(I) . poly(C).

Abstract

Encephalomyocarditis (EMC) virus causes lethal infection of hamsters against which poly(I) . poly(C) causes dose-dependent protection. In contrast, no antiviral effects occur with poly(I) . poly(C) against influenza virus infection of hamsters. Serum from poly(I) . poly(C) treated hamsters protects other hamsters against EMC virus infection with maximum protection with serum removed 3h after poly(I) . poly(C) treatment of the donor hamsters. In such assays the factor was found to be inactivated by trypsin and pH 2 and 56 degrees C for 1 hr. The serum factor did not confer protection against EMC virus infection of L-929, BHK, Hak or primary hamster embryo cells. The amount of poly(I) . poly(C) carried over into serum samples of poly(I) . poly(C) treated hamsters was insufficient to account for the antiviral effects. The antiviral serum factor is presumed to be a form of interferon despite the fact that it does not titrate in cell cultures and has a novel set of properties from those which describe known interferons.

• Authors: E M Round, N Stebbing
• Journal: Journal of interferon research (J Interferon Res) Vol. 1 Issue 3 Pg. 451-6 ( 1981) ISSN: 0197-8357 [Print] United States
• PMID: 6180078 (Publication Type: Journal Article)

Chemical References

• Interferons
• Poly I-C

Topics

• Animals
• Cricetinae (physiology)
• Encephalomyocarditis virus
• Enterovirus Infections (immunology)
• Interferons (biosynthesis)
• Mesocricetus (physiology)
• Poly I-C (pharmacology)