Intracranial germ cell tumor indicating a high level of alpha-fetoprotein (AFP).

Abstract

An autopsy case of intracranial and extrapineal tumor is reported. The tumor, detected 2 years and 4 months before death, was an ectopic pinealoma (germ cell tumor) and showed elevated serum alpha-fetoprotein (AFP) of 48,000 ng/ml. Histologically, intra- and extracellular PAS-positive hyaline globules were observed in the tumor. The tumor tissues of the paraffin sections revealed a bright positive fluorescence for AFP with indirect immunofluorescence method. Besides, there were generalized metastases in this case.

• Authors: M Tsuchiyama, M Miyamoto, M Sakurai, H Kitamura
• Journal: Acta pathologica japonica (Acta Pathol Jpn) Vol. 31 Issue 3 Pg. 521-6 (May 1981) ISSN: 0001-6632 [Print] Australia
• PMID: 6168166 (Publication Type: Case Reports, Journal Article)

Chemical References

• alpha-Fetoproteins

Topics

• Adult
• Brain Neoplasms (analysis, pathology)
• Humans
• Male
• Pinealoma (analysis, pathology)
• alpha-Fetoproteins (analysis)