Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells.

Abstract

Nine human breast fibroadenomas, initially negative for D-type retrovirus interspecies-specific antigen, do not produce that antigen during 6 months of cocultivation with bat lung cells. However, 3 out of 5 human breast fibroadenomas, already positive for D-type virus interspecies-specific antigen before cultivation, are able to induce a transient D-type retrovirus interspecies-specific antigen production after 3 to 4 months of cocultivation with bat lung cells. The antigen is detectable both in cocultivated cells and in pellets sedimented from the coculture fluid. It is concluded that D-type retroviruses are associated with human breast fibroadenomas.

• Authors: K V Ilyin, V A Morozov
• Journal: Archiv fur Geschwulstforschung (Arch Geschwulstforsch) Vol. 50 Issue 8 Pg. 743-6 ( 1980) ISSN: 0003-911X [Print] Germany
• PMID: 6164351 (Publication Type: Journal Article)

Chemical References

• Antigens, Viral
• Epitopes

Topics

• Adenofibroma (immunology, microbiology)
• Animals
• Antigens, Viral (analysis)
• Breast Neoplasms (immunology, microbiology)
• Cells, Cultured
• Chiroptera
• Epitopes
• Humans
• Lung (microbiology)
• Male
• Retroviridae Infections (immunology, microbiology)
• Species Specificity