Orcein-positive hepatitis B surface antigen and liver carcinoma: their association in an Eastern US population.

Abstract

We retrospectively examined the association of hepatitis B infection and hepatocellular carcinoma (HCC) in a US East Coast population using orcein staining of fixed liver tissue. Hepatitis B surface antigen (HBsAg) was present in non-neoplastic hepatocytes in eight of 53 cases of HCC, but in no cases of cholangiocarcinoma or metastatic tumor. In five of the eight positive cases, macronodular cirrhosis was present; in three positive cases, cirrhosis was absent. The rate of positivity in livers with both HCC and macronodular cirrhosis was 28%, compared with 4.7% in livers with macronodular cirrhosis but no carcinoma. The low, but significant association of HBsAg and HCC, both in the presence and absence of cirrhosis, suggests that HCC may develop in a subset of patients in the United States as a result of infection with hepatitis B virus.

• Authors: A A Keshgegian, R H Ochs
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 105 Issue 4 Pg. 190-3 (Apr 1981) ISSN: 0003-9985 [Print] United States
• PMID: 6163416 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Hepatitis B Surface Antigens
• Oxazines
• PAcein

Topics

• Adenoma, Bile Duct (immunology)
• Carcinoma, Hepatocellular (immunology)
• Female
• Hepatitis B (complications)
• Hepatitis B Surface Antigens (isolation & purification)
• Humans
• Liver Cirrhosis (complications, immunology)
• Liver Neoplasms (immunology)
• Male
• Oxazines
• Retrospective Studies
• Staining and Labeling