Close relationship of Crimean hemorrhagic fever-Congo (CHF-C) virus strains by neutralizing antibody assays.

Abstract

Strains of Crimean hemorrhagic fever-Congo (CHF-C) virus originating in widely separated points representing diverse zoogeograhiczl and ecological areas were compared by a neutralization of fluorescent foci of infection-test, in an attempt to determine whether antigenic differences could be detected among the strains. Minor differences were found which could be confirmed by reciprocal kinetic neutralization tests with one-injection immune sera if the results were analyzed by linear regression. However, CHF-C virus strains cannot be reliably subdivided into geographic variants on the basis of the minor antigenic variations observed. In this apparent paucity of antigenic diversity over its wide distribution, CHF-C virus differs from other arboviruses with similar or even lesser distribution.

• Authors: G H Tignor, A L Smith, J Casals, C D Ezeokoli, J Okoli
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 29 Issue 4 Pg. 676-85 (Jul 1980) ISSN: 0002-9637 [Print] United States
• PMID: 6157333 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Viral
• Epitopes

Topics

• Animals
• Antibodies, Viral (analysis)
• Epitopes
• Guinea Pigs
• Hemorrhagic Fever Virus, Crimean-Congo (immunology)
• Hemorrhagic Fever, Crimean (immunology)
• Neutralization Tests
• Temperature