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Sustained remission of choriocarcinoma with cis-platinum, vinblastine, and bleomycin after failure of conventional combination drug therapy.

Abstract
Combination chemotherapy with methotrexate, actinomycin D. and an alkylating agent (MAC) has become widely used for patients with "high-risk" gestational choriocarcinoma. When such chemotherapy fails to obliterate this disease the prognosis has been uniformly poor. Chemotherapy failure may result from excessive toxicity or tumor resistance. Two patients are presented who failed treatment with MAC. Both have achieved sustained clinical and serum beta subunit-hCG titer remission of choriocarcinoma with the use of the drugs cis-platinum, vinblastine, and bleomycin.
AuthorsJ B Schlaerth, C P Morrow, A D DePetrillo
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 136 Issue 8 Pg. 983-5 (Apr 15 1980) ISSN: 0002-9378 [Print] United States
PMID6154417 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Bleomycin
  • Vinblastine
  • Cisplatin
Topics
  • Adult
  • Antineoplastic Agents (administration & dosage)
  • Bleomycin (administration & dosage)
  • Choriocarcinoma (drug therapy, secondary)
  • Cisplatin (administration & dosage)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hydatidiform Mole (surgery)
  • Ovarian Neoplasms (drug therapy)
  • Pregnancy
  • Remission, Spontaneous
  • Teratoma (drug therapy)
  • Uterine Neoplasms (drug therapy, surgery)
  • Vinblastine (administration & dosage)

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