Haemodynamic effects of prenaterol and cardiac glycosides in patients with recent myocardial infarction.

Prenalterol was given to twenty five patients with acute myocardial infarction. Thirteen patients (group B) had signs of cardiac decompensation while twelve (group A) had not. Ejection fraction was determined with 99mTc-labelled red blood cells before and after prenalterol (50 micrograms kg-1 body weight), intravenously. In group B this procedure was repeated after digitalization 2 days later. The ejection fraction increased significantly in group A after prenalterol injection. In group B, prenalterol produced an increase, but this was not significant. After digitalis the ejection fraction increased significantly and prenalterol produced an additional significant rise. No significant changes in blood pressure occurred. Heart rate increased significantly in both groups after prenalterol injection and decreased significantly after digitalis.
AuthorsP A Boström, J Andersson, B W Johansson, B Lilja, J Thorell, K Tidfält, S Westerling
JournalEuropean journal of clinical investigation (Eur J Clin Invest) Vol. 14 Issue 3 Pg. 175-80 (Jun 1984) ISSN: 0014-2972 [Print] ENGLAND
PMID6147253 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Agonists
  • Digoxin
  • Technetium
  • Prenalterol
  • Practolol
  • Adrenergic beta-Agonists (pharmacology, therapeutic use)
  • Aged
  • Blood Pressure (drug effects)
  • Cardiac Output (drug effects)
  • Digoxin (therapeutic use)
  • Drug Therapy, Combination
  • Erythrocytes
  • Female
  • Heart (radionuclide imaging)
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Myocardial Contraction (drug effects)
  • Myocardial Infarction (drug therapy)
  • Practolol (analogs & derivatives, pharmacology, therapeutic use)
  • Prenalterol
  • Stimulation, Chemical
  • Stroke Volume (drug effects)
  • Technetium

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