[Ketoconazole-induced hepatitis. Case report].

Abstract

Since Oct. 1981 a new systemic antifungal drug Ketoconazole is available in the Federal Republic of Germany that has proven effective even in severe cases with fungal infections. This case-study will call attention on a rare but important side effect, namely Ketoconazole induced hepatitis. As an acute icteric viral hepatitis, type Non-A-Non-B-hepatitis possibly misdiagnosed only a carefully compiled history of the recent intake of drugs points at the real cause of hepatitis. In our case-report we observed a considerable increase in serum enzymes, especially GOT, GPT and GLDH after a drug-challenge with two tablets. We recommend so-called liver functions tests 2 to 3 weeks after beginning of therapy and further-on in monthly intervals. Histologically at that time toxic hydropic changes of the liver cells and a mesenchymal reaction with portal and intralobular mainly eosinophilic infiltration could be established. The serum enzymes came to normal only after 12 weeks.

• Authors: H Henning, B Kasper, C J Lüders
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 21 Issue 12 Pg. 709-15 (Dec 1983) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Ketoconazol-induzierte Hepatitis. Eine Kasuistik.
• PMID: 6141674 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• gamma-Glutamyltransferase
• Aspartate Aminotransferases
• Alanine Transaminase
• Ketoconazole

Topics

• Alanine Transaminase (blood)
• Aspartate Aminotransferases (blood)
• Chemical and Drug Induced Liver Injury (diagnosis, enzymology, etiology)
• Female
• Humans
• Ketoconazole (adverse effects, therapeutic use)
• Laparoscopy
• Middle Aged
• Onychomycosis (drug therapy)
• gamma-Glutamyltransferase (blood)