Topical cholesterol treatment of recessive X-linked ichthyosis.

Abstract

In an open prospective half-side trial, creams containing 10% cholesterol or 10% urea were applied to lesions in 20 steroid-sulphatase-deficient male patients with recessive X-linked ichthyosis. In 18 there was a good response to the cholesterol cream. In 13 patients the response to cholesterol was better than that to urea. None showed a better response to urea than to cholesterol. A reduction in the cholesterol content of the stratum corneum may be responsible for abnormal cornification in recessive X-linked ichthyosis.

• Authors: G Lykkesfeldt, H Høyer
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8363 Pg. 1337-8 (Dec 10 1983) ISSN: 0140-6736 [Print] England
• PMID: 6139672 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Cholesterol Esters
• Cholesterol
• cholesteryl sulfate

Topics

• Administration, Topical
• Adolescent
• Adult
• Child
• Child, Preschool
• Cholesterol (administration & dosage)
• Cholesterol Esters (administration & dosage)
• Clinical Trials as Topic
• Genes, Recessive
• Genetic Linkage
• Humans
• Ichthyosis (drug therapy, genetics)
• Infant
• Male
• Prospective Studies