Triazolam treatment of insomnia in depressed patients taking tricyclics.

A double-blind crossover study in 53 psychiatric outpatients compared the safety and efficacy of triazolam and placebo in relieving insomnia refractory to treatment with a tricyclic antidepressant. Patients with a depressive disorder who had been taking a TCA for at least 6 weeks received triazolam or placebo for 4 days, neither medication for 1 day, and the alternative treatment for 4 days. The antidepressant regimen was maintained throughout the study. Sleep measurements showed triazolam to be consistently more effective than placebo in promoting and maintaining sleep and enabling the patient to awaken feeling rested. No worsening in depression or anxiety was seen with either triazolam or placebo; some measures indicated improvement in anxiety and depression symptoms on triazolam. One patient on triazolam dropped out because of side effects. The most common side effect was mild to moderate drowsiness.
AuthorsJ B Cohn
JournalThe Journal of clinical psychiatry (J Clin Psychiatry) Vol. 44 Issue 11 Pg. 401-6 (Nov 1983) ISSN: 0160-6689 [Print] UNITED STATES
PMID6139364 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Anxiety Agents
  • Antidepressive Agents, Tricyclic
  • Triazolam
  • Adult
  • Anti-Anxiety Agents (therapeutic use)
  • Antidepressive Agents, Tricyclic (therapeutic use)
  • Clinical Trials as Topic
  • Depressive Disorder (complications, drug therapy)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Sleep Initiation and Maintenance Disorders (complications, drug therapy)
  • Triazolam (adverse effects, therapeutic use)

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