Fetal pulmonary maturity: relationship between optical density (650 nm) to the lecithin/sphingomyelin ratio and phosphatidylglycerol in amniotic fluid.

Abstract

An optical density value greater than or equal to 0.15 at A650 n m of amniotic fluid obtained through transabdominal amniocentesis from a high risk obstetrical population, which excluded diabetes mellitus, isoimmunization, and amniotic fluid infection, correlated 98.6% with a mature lecithin to sphingomyelin ratio (L/S) greater than or equal to 2.0% and 41.6% with the presence of phosphatidylglycerol (PG). The corresponding false positive rates were 1.4% and 16.8%, respectively. In 30 infants delivered within 48 h of testing, A650 n m greater than or equal to 0.15 correlated 100% with absence of respiratory distress syndrome. A650 n m is not recommended for Rhesus immunized gestations, diabetic pregnancies and amniotic fluid infection due to a high false positive rate with A650 nm compared to L/S and PG.

• Authors: S Moodley, J H Liu, R C Cherkis, R K Miller, T A Merrit, L E Whalen
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 21 Issue 3 Pg. 199-203 (Jun 1983) ISSN: 0020-7292 [Print] United States
• PMID: 6139307 (Publication Type: Journal Article)

Chemical References

• Phosphatidylcholines
• Phosphatidylglycerols
• Sphingomyelins

Topics

• Amniotic Fluid (analysis, physiology)
• Female
• Fetal Membranes, Premature Rupture (physiopathology)
• Fetal Organ Maturity
• Humans
• Infant, Newborn
• Lung (embryology)
• Phosphatidylcholines (analysis)
• Phosphatidylglycerols (analysis)
• Pregnancy
• Respiratory Distress Syndrome, Newborn (diagnosis)
• Retrospective Studies
• Sphingomyelins (analysis)