HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.

Abstract
A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-globin mRNA ratio, and was translated normally. No detectable zeta-globin mRNA was found. The alpha- and zeta-globin genes were both hypomethylated and restriction endonuclease maps of the alpha- and zeta-globin genes were comparable in the patient's marrow and fibroblast DNA. The data are most consistent with the acquisition of a mutation(s) that resulted in decreased expression of all four alpha-globin genes.
AuthorsN P Anagnou, T J Ley, B Chesbro, G Wright, C Kitchens, S Liebhaber, A W Nienhuis, A B Deisseroth
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 80 Issue 19 Pg. 6051-5 (Oct 1983) ISSN: 0027-8424 [Print] United States
PMID6136971 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA, Recombinant
  • RNA, Messenger
  • Poly A
  • Globins
  • DNA Restriction Enzymes
Topics
  • Aged
  • Base Sequence
  • DNA Restriction Enzymes
  • DNA, Recombinant
  • Genes
  • Globins (deficiency, genetics)
  • Humans
  • Male
  • Nucleic Acid Hybridization
  • Poly A (genetics)
  • Preleukemia (complications, genetics)
  • Protein Biosynthesis
  • RNA, Messenger (genetics)
  • Thalassemia (complications, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: