Oxyhaemoglobin equilibrium and chronic beta-adrenoceptor blockade in coronary heart disease.

In 20 patients with coronary heart disease the effect of long-term beta-adrenergic receptor blockade on the haemoglobin oxygen equilibrium was investigated. Study patients received alprenolol 200 mg twice daily for 12-41 months (mean: 24 months) as a secondary preventive measure following a myocardial infarction. While on and again following gradual withdrawal of alprenolol, the patients performed a maximum bicycle ergometer test. Haemoglobin oxygen affinity as expressed by the P50 value, 2,3-diphosphoglycerate (2,3-DPG) and carbon monoxide haemoglobin were measured before and following exercise. Pre-exercise P50 decreased from 25.2 +/- 0.3 mm Hg (mean +/- s.e. mean) while on beta-adrenoceptor blocker to 24.6 +/- 0.4 mm Hg in the off-treatment state (P less than 0.05). Five minutes after stopping exercise P50 was 25.1 +/- 0.3 in patients taking alprenolol as compared to 24.7 +/- 0.3 after withdrawal of the drug (P less than 0.01). It is concluded that the slight decrease in haemoglobin oxygen affinity in long-term treatment with alprenolol, which is observed in the present study probably is without clinical bearing. The question should be further elucidated by analysis of coronary sinus blood samples.
AuthorsH J Jürgensen, P D Wimberley, U Brodthagen
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 16 Issue 1 Pg. 33-8 (Jul 1983) ISSN: 0306-5251 [Print] ENGLAND
PMID6136291 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Diphosphoglyceric Acids
  • Hemoglobins
  • Oxyhemoglobins
  • 2,3-Diphosphoglycerate
  • 2,3-Diphosphoglycerate
  • Adrenergic beta-Antagonists (therapeutic use)
  • Adult
  • Aged
  • Coronary Disease (blood, drug therapy)
  • Diphosphoglyceric Acids (blood)
  • Erythrocytes (metabolism)
  • Female
  • Heart Rate (drug effects)
  • Hemoglobins (metabolism)
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Oxyhemoglobins (metabolism)
  • Physical Exertion

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