HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Oxyhaemoglobin equilibrium and chronic beta-adrenoceptor blockade in coronary heart disease.

Abstract
In 20 patients with coronary heart disease the effect of long-term beta-adrenergic receptor blockade on the haemoglobin oxygen equilibrium was investigated. Study patients received alprenolol 200 mg twice daily for 12-41 months (mean: 24 months) as a secondary preventive measure following a myocardial infarction. While on and again following gradual withdrawal of alprenolol, the patients performed a maximum bicycle ergometer test. Haemoglobin oxygen affinity as expressed by the P50 value, 2,3-diphosphoglycerate (2,3-DPG) and carbon monoxide haemoglobin were measured before and following exercise. Pre-exercise P50 decreased from 25.2 +/- 0.3 mm Hg (mean +/- s.e. mean) while on beta-adrenoceptor blocker to 24.6 +/- 0.4 mm Hg in the off-treatment state (P less than 0.05). Five minutes after stopping exercise P50 was 25.1 +/- 0.3 in patients taking alprenolol as compared to 24.7 +/- 0.3 after withdrawal of the drug (P less than 0.01). It is concluded that the slight decrease in haemoglobin oxygen affinity in long-term treatment with alprenolol, which is observed in the present study probably is without clinical bearing. The question should be further elucidated by analysis of coronary sinus blood samples.
AuthorsH J Jürgensen, P D Wimberley, U Brodthagen
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 16 Issue 1 Pg. 33-8 (Jul 1983) ISSN: 0306-5251 [Print] ENGLAND
PMID6136291 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Diphosphoglyceric Acids
  • Hemoglobins
  • Oxyhemoglobins
  • 2,3-Diphosphoglycerate
Topics
  • 2,3-Diphosphoglycerate
  • Adrenergic beta-Antagonists (therapeutic use)
  • Adult
  • Aged
  • Coronary Disease (blood, drug therapy)
  • Diphosphoglyceric Acids (blood)
  • Erythrocytes (metabolism)
  • Female
  • Heart Rate (drug effects)
  • Hemoglobins (metabolism)
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Oxyhemoglobins (metabolism)
  • Physical Exertion

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: