Ocular toxicity of high-dose intravenous desferrioxamine.

Abstract	Desferrioxamine was given intravenously, at higher doses than previously reported, to counter the effects of transfusion-induced iron overload in four patients with beta thalassaemia major. In two of them retinal abnormalities developed, presenting with night blindness and field defects, which improved on withdrawal of the drug.
Authors	S C Davies, R E Marcus, J L Hungerford, M H Miller, G B Arden, E R Huehns
Journal	Lancet (London, England) (Lancet) Vol. 2 Issue 8343 Pg. 181-4 (Jul 23 1983) ISSN: 0140-6736 [Print] England
PMID	6135026 (Publication Type: Case Reports, Journal Article)
Chemical References	Iron Deferoxamine
Topics	Adolescent Adult Cataract (chemically induced) Child Child, Preschool Dark Adaptation (drug effects) Deferoxamine (administration & dosage, adverse effects) Female Follow-Up Studies Humans Infant Infusions, Parenteral Iron (poisoning) Male Photoreceptor Cells (drug effects) Scotoma (chemically induced) Thalassemia (therapy) Transfusion Reaction Visual Acuity (drug effects) Visual Fields (drug effects)

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