The present experiment was carried out to elucidate the effectiveness of
oxatomide for prophylaxis in the bronchial
anaphylaxis and Schultz-Dale response. 1)
Oxatomide administered i.v. was found to be as active as
disodium cromoglycate (DSCG) in inhibiting
IgE-mediated active anaphylactic bronchoconstrictions in rats. In contrast to DSCG,
oxatomide was effective when administered p.o. 2) Passive anaphylactic broncho-constrictions in guinea pigs mediated
IgG-like rabbit antibody against egg
albumin was also prevented dose-dependently by treatment with
oxatomide given p.o. and i.v., but not by DSCG. 3)
Oxatomide and DSCG inhibited passive anaphylactic bronchoconstrictions in guinea pigs mediated by
IgE-like antibody against BPO X BGG. 4) The
anaphylactic reaction of the isolated guinea pig ileum, the so-called Schultz-Dale reaction, showed a bi-phasic response: a short, rapid contraction followed by a partial relaxation and a slow contractile response.
Oxatomide significantly depressed both the rapid first contraction and the slow sustained one. 5)
Oxatomide administered after the development of
antigen-induced contraction of isolated guinea pig trachea resulted in relaxation. These results suggest that
oxatomide may be effective for the treatment of allergic
bronchial asthma.