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[Pharmacological actions of oxatomide (KW-4354). 3. Actions on experimental asthma and Schultz-Dale reaction].

Abstract
The present experiment was carried out to elucidate the effectiveness of oxatomide for prophylaxis in the bronchial anaphylaxis and Schultz-Dale response. 1) Oxatomide administered i.v. was found to be as active as disodium cromoglycate (DSCG) in inhibiting IgE-mediated active anaphylactic bronchoconstrictions in rats. In contrast to DSCG, oxatomide was effective when administered p.o. 2) Passive anaphylactic broncho-constrictions in guinea pigs mediated IgG-like rabbit antibody against egg albumin was also prevented dose-dependently by treatment with oxatomide given p.o. and i.v., but not by DSCG. 3) Oxatomide and DSCG inhibited passive anaphylactic bronchoconstrictions in guinea pigs mediated by IgE-like antibody against BPO X BGG. 4) The anaphylactic reaction of the isolated guinea pig ileum, the so-called Schultz-Dale reaction, showed a bi-phasic response: a short, rapid contraction followed by a partial relaxation and a slow contractile response. Oxatomide significantly depressed both the rapid first contraction and the slow sustained one. 5) Oxatomide administered after the development of antigen-induced contraction of isolated guinea pig trachea resulted in relaxation. These results suggest that oxatomide may be effective for the treatment of allergic bronchial asthma.
AuthorsK Ohmori, H Ishii, Y Takei, K Shuto, N Nakamizo
JournalNihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 80 Issue 6 Pg. 481-93 (Dec 1982) ISSN: 0015-5691 [Print] Japan
PMID6131021 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Bronchodilator Agents
  • Histamine H1 Antagonists
  • Piperazines
  • oxatomide
  • Cromolyn Sodium
Topics
  • Animals
  • Asthma (drug therapy, immunology)
  • Bronchi (immunology)
  • Bronchodilator Agents
  • Cromolyn Sodium (therapeutic use)
  • Guinea Pigs
  • Histamine H1 Antagonists (pharmacology)
  • Ileum (drug effects, immunology)
  • In Vitro Techniques
  • Male
  • Piperazines (pharmacology, therapeutic use)
  • Rabbits
  • Rats
  • Rats, Inbred Strains

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