Are the prejunctional histamine receptors on sympathetic nerve terminals in guinea-pig isolated atria activated during anaphylaxis in vitro?

Abstract

In isolated atria from sensitized guinea-pigs, antigenic challenge with ovalbumin induces an anaphylactic reaction in which there is an increased rate and force of contraction. At the same time, stimulation-induced release of [3H] noradrenaline is inhibited by 40%. Cimetidine decreased the tachycardia occurring during anaphylaxis but no effect on the inhibition of stimulation-induced transmitter release. It is known that antigenic challenge of sensitized guinea-pig atria release histamine from mast cells; this histamine acts postjunctionally to increase heart rate. However, the inhibition of noradrenergic transmitter release is not due to the stimulation of prejunctional inhibitory histamine receptors.

• Authors: H Wong-Dusting, D F Story, M J Rand
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 34 Issue 10 Pg. 653-7 (Oct 1982) ISSN: 0022-3573 [Print] England
• PMID: 6128388 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Histamine
• Cimetidine
• Ovalbumin
• Norepinephrine

Topics

• Anaphylaxis (physiopathology)
• Animals
• Cimetidine (pharmacology)
• Female
• Guinea Pigs
• Heart (innervation)
• Heart Rate (drug effects)
• In Vitro Techniques
• Male
• Nerve Endings (metabolism)
• Norepinephrine (physiology)
• Ovalbumin (immunology)
• Receptors, Histamine (physiology)
• Sympathetic Nervous System (metabolism)