Effect of intravenous prenalterol on haemodynamics and myocardial lactate extraction in patients with left ventricular failure.

Abstract

To assess the immediate haemodynamic and myocardial metabolic effects of the beta 1-agonist prenalterol, we studied by cardiac catheterisation the response to 50 and 100 micrograms/kg given intravenously in 16 patients with congestive heart failure secondary to coronary artery disease or non-ischaemic cardiomyopathy. At peak effect, cardiac index increased from 2.6 +/- 0.5 to 3.2 +/- 0.8 1/min/m2 (mean +/- SD) p less than 0.001); peak rate of left ventricular pressure development rose from 963 +/- 242 to 1355 +/- 411 mm Hg per second (p less than 0.001); left ventricular end-diastolic pressure fell from 27 +/- 6 to 13 +/- 7 mm Hg (p less than 0.001); coronary sinus blood flow increased from 120 +/- 39 to 147 +/- 55 ml/min (p less than 0.01); myocardial oxygen consumption was augmented from 12.9 +/- 3.9 to 15.7 +/- 5.8 ml/min (p less than 0.001); and heart rate increased slightly (76 +/- 12 to 86 +/- 14 beats per minute, p less than 0.05). No significant changes occurred in left ventricular systolic pressure, stroke volume index, myocardial lactate extraction rate, myocardial arteriovenous oxygen difference and no patient developed angina, ECG-changes or ventricular arrhythmias. Infusion of prenalterol effectively improved the haemodynamic function and cardiac metabolism in congestive cardiomyopathy.

• Authors: W Kupper, M Schütt, W Bleifeld
• Journal: Acta medica Scandinavica. Supplementum (Acta Med Scand Suppl) Vol. 659 Pg. 287-98 ( 1982) ISSN: 0365-463X [Print] Sweden
• PMID: 6127895 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Lactates
• Prenalterol
• Practolol

Topics

• Adrenergic beta-Agonists (pharmacology)
• Adult
• Blood Pressure (drug effects)
• Cardiac Catheterization
• Cardiac Output (drug effects)
• Coronary Circulation (drug effects)
• Heart (drug effects)
• Heart Failure (metabolism)
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Humans
• Infusions, Parenteral
• Lactates (metabolism)
• Middle Aged
• Myocardium (metabolism)
• Oxygen Consumption (drug effects)
• Practolol (administration & dosage, analogs & derivatives, pharmacology)
• Prenalterol