An open and double-blind cross-over study on the efficacy of clomipramine (Anafranil) in patients with painful mono- and polyneuropathies.

82 patients with chronic pain resulting from mononeuropathy were treated with psychotropic drugs in an open therapeutic study. In this study we found that treatment with a combination of clomipramine (Anafranil) and small doses of neuroleptics was significantly superior to therapy with neuroleptics alone. In a subsequent double-blind study, it was attempted for the first time to determine the efficacy of clomipramine compared to that of acetylsalicylic acid in 48 patients with painful mono- and polyneuropathies. The test was carried out in a cross-over trial with two sequence groups. We evaluated assessments of pain by both patients and doctors, and were able to prove statistically that clomipramine possesses a significantly greater efficacy compared to that of acetylsalicylic acid. By taking into account recent anatomical, biochemical and pharmacological studies, it can be concluded that clomipramine probably has-in addition to the action on peripheral receptors-a direct effect upon pain modulation systems. It seems possible that clomipramine activates serotonin-containing neurons of the endorphin-mediated analgesia system that control pain transmission in the CNS.
AuthorsH D Langohr, M Stöhr, F Petruch
JournalEuropean neurology (Eur Neurol) Vol. 21 Issue 5 Pg. 309-17 ( 1982) ISSN: 0014-3022 [Print] SWITZERLAND
PMID6126361 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Clomipramine
  • Aspirin
  • Antipsychotic Agents (therapeutic use)
  • Aspirin (therapeutic use)
  • Causalgia (drug therapy)
  • Clinical Trials as Topic
  • Clomipramine (therapeutic use)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuralgia (drug therapy)
  • Neuritis (drug therapy)
  • Phantom Limb (drug therapy)
  • Polyneuropathies (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: