Effects of dapiprazole on pupillary size and intraocular pressure in rabbits.

Abstract

The effects of 3-[2-[4-(2-methylphenyl)-1- piperazinyl]ethyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine HCl (dapiprazole), a new drug with alpha-adrenergic blocking properties, on pupillary diameter and intraocular pressure have been studied in rabbits. Following i.v. administration, a reduction of intraocular pressure is observed at doses devoid of activity on pupillary diameter. Following topical application, a miotic and ocular hypertensive action was observed at the same doses; the hypotensive action is produced in both normal rabbits and in rabbits with water load- or corticosteroid-induced ocular hypertension. Contact lenses increase the duration of effects of dapiprazole. These results suggest a potential interest of dapiprazole in glaucoma, with particular reference to the topical treatment of angle-closure glaucoma.

• Authors: B Silvestrini, L Bonomi, R Lisciani, S Perfetti, R Belluci, F Massa, A Baldini
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 32 Issue 6 Pg. 678-81 ( 1982) ISSN: 0004-4172 [Print] Germany
• PMID: 6126199 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Antipsychotic Agents
• Piperazines
• Triazoles
• Water
• dapiprazole
• Clonidine

Topics

• Administration, Topical
• Adrenal Cortex Hormones (pharmacology)
• Animals
• Antipsychotic Agents (pharmacology)
• Clonidine (pharmacology)
• Drug Interactions
• Female
• Injections, Intravenous
• Intraocular Pressure (drug effects)
• Male
• Piperazines
• Pupil (drug effects)
• Rabbits
• Triazoles (pharmacology)
• Water (pharmacology)