Autoimmune thrombocytopenia acquired from an allogeneic bone-marrow graft.

Abstract

Severe thrombocytopenia developed after an allogeneic bone-marrow graft in a 40-year-old woman in first remission from acute myeloblastic leukaemia. The thrombocytopenia had an autoimmune basis and was acquired from the bone-marrow donor who had an identical platelet autoantibody. The patient responded to high-dose intravenous IgG, and she has a normal platelet count 10 months after the graft. This study suggests that the immune defect in autoimmune thrombocytopenia can be transferred in cells capable of proliferating in a bone-marrow graft.

• Authors: R M Minchinton, A H Waters, J Kendra, A J Barrett
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8299 Pg. 627-9 (Sep 18 1982) ISSN: 0140-6736 [Print] England
• PMID: 6125775 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Immunoglobulin G
• Immunoglobulin M

Topics

• Adult
• Autoantibodies (analysis)
• Blood Platelets (immunology)
• Bone Marrow Transplantation
• Female
• Humans
• Immunoglobulin G (administration & dosage)
• Immunoglobulin M (analysis, immunology)
• Leukemia, Myeloid, Acute (therapy)
• Postoperative Complications (blood)
• Thrombocytopenia (etiology, immunology, therapy)