Single-dose penicillin prophylaxis of neonatal group-B-streptococcal disease.

Abstract

The efficacy of a single dose of aqueous penicillin G in preventing neonatal group-B streptococcal infections was demonstrated in a randomised study conducted over 41 months. 16 082 infant received a single dose of penicillin within one hour of delivery, and 15 976 infants who received tetracycline ophthalmic ointment served as the control group. Group-B streptococcal systemic infections were significantly less common in the penicillin-treated infants (0.6 vs 1.7 cases per 100 live birth, p = 0.004). The incidence of infection caused by penicillin-resistant pathogen was insignificantly increased in the penicillin group (2.2 vs 1.6 cases per thousand live birth, p = 0.32). this difference was accounted for almost completely by the events of the first 12 months of the study period when, for unexplained reasons, there was a considerable increase in the number of penicillin-resistant infections in the penicillin group (3.6 vs 1.4 cases per 1000 live births, p = 0.09). The mortality associated with penicillin-susceptible pathogens was higher in the control group (0.1 vs 0.4 per 1000 live births, p = 0.18). However, the mortality associated with penicillin-resistant pathogens was increased in the penicillin (0.4 vs 1.0 per 1000 live births, p = 0.06). The combined mortality rates for all pathogens were not significantly different (1.1 vs 0.7 per 1000 liver births, p = 0.27, for the penicillin and control groups, respectively) and were nearly equivalent when the excess number of deaths associated with penicillin-resistant infections in the penicillin group during the first study year was excluded from analysis. The incidence of gonococcal ophthalmia and conjunctivitis was unaffected by the use of intramuscular penicillin at birth.

• Authors: J D Siegel, G H McCracken Jr, N Threlkeld, B M DePasse, C R Rosenfeld
• Journal: Lancet (London, England) (Lancet) Vol. 1 Issue 8287 Pg. 1426-30 (Jun 26 1982) ISSN: 0140-6736 [Print] England
• PMID: 6123719 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Penicillin G

Topics

• Clinical Trials as Topic
• Humans
• Infant, Newborn
• Infant, Newborn, Diseases (prevention & control)
• Injections, Intramuscular
• Penicillin G (administration & dosage)
• Penicillin Resistance
• Random Allocation
• Serotyping
• Streptococcal Infections (prevention & control)
• Streptococcus agalactiae (classification, drug effects)