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Treatment of hyperprolactinaemia with pergolide mesylate: acute effects and preliminary evaluation of long-term treatment.

Abstract
The acute and long-term effects of oral pergolide mesylate, a new potent, long-acting dopamine agonist, were investigated in 10 hyperprolactinaemic patients. After a single 50 micrograms dose of pergolide mesylate, serum prolactin concentrations fell steadily to reach a mean minimum value at 6 h of 20% of baseline values; this degree of suppression was maintained throughout the 24 h study period. In one patient serum prolactin was measured for 2 days after a single dose and remained suppressed for 45 h. There were no acute changes in the serum concentration of luteinising hormone, follicle-stimulating hormone and growth hormone. Preliminary evaluation of longer term treatment with pergolide indicates that this drug at a once-daily dose of 50-150 micrograms is a safe, well tolerated, and effective new treatment for hyperprolactinaemia.
AuthorsS Franks, P M Horrocks, S S Lynch, W R Butt, D R London
JournalLancet (London, England) (Lancet) Vol. 2 Issue 8248 Pg. 659-61 (Sep 26 1981) ISSN: 0140-6736 [Print] England
PMID6116045 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Ergolines
  • Pergolide
  • Bromocriptine
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Growth Hormone
Topics
  • Administration, Oral
  • Adult
  • Bromocriptine (adverse effects)
  • Depression, Chemical
  • Ergolines (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Follicle Stimulating Hormone (blood)
  • Growth Hormone (blood)
  • Humans
  • Luteinizing Hormone (blood)
  • Male
  • Pergolide
  • Prolactin (blood)
  • Time Factors

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