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[Prenalterol (CGP 7760 B), a new cardioselective beta 1-adrenoceptor-agonist (author's transl)].

Abstract
The haemodynamic effects of the new selective beta 1-receptor-agonist prenalterol were investigated in two groups each of 8 patients. Dosages of 500 microgram/5 min and 100 microgram/1 min were given after direct closure of atrial septal defect under neuroleptanalgesia. Prenalterol 500 microgram/5 min increased cardiac index (37.5%), heart rate (19%), stroke index (16.2%), mean arterial pressure (26.5%) and dp/dtmax (84.5%) significantly. Total systemic resistance, total pulmonary vascular resistance and mean pulmonary pressure remained constant. Filling pressures of both ventricles decreased slightly but significantly. Maximal hemodynamic changes after infusion of 100 microgram/1 min prenalterol were half as great as with 500 microgram/5 min and occurred 3 min earlier. The haemodynamic action of prenalterol was rather long lasting. One hour after cessation of the drug-infusion there were still detectable haemodynamic effects. In contrast to investigations in awake patients there was a greater increase in heart rate, which is referred to influences on the vagal reflex caused by anaesthesia.
AuthorsS Piepenbrock, W Reichelt, M Zenz, W Seitz, E Sikalieh
JournalDer Anaesthesist (Anaesthesist) Vol. 30 Issue 3 Pg. 118-23 (Mar 1981) ISSN: 0003-2417 [Print] GERMANY, WEST
Vernacular TitlePrenalterol (CGP 7760 B), ein neuer kardioselektiver beta 1-Rezeptoren-Agonist.
PMID6111933 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Cardiotonic Agents
  • Prenalterol
  • Practolol
Topics
  • Adrenergic beta-Antagonists
  • Adult
  • Blood Pressure (drug effects)
  • Cardiac Volume (drug effects)
  • Cardiotonic Agents
  • Female
  • Heart Rate (drug effects)
  • Hemodynamics (drug effects)
  • Humans
  • Male
  • Practolol (administration & dosage, analogs & derivatives, pharmacology)
  • Prenalterol
  • Vascular Resistance (drug effects)

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