Studies of circulation and acid-base balance in pregnant sheep: I. The effect of aminophylline infusion.

Abstract

The maternal and fetal effects of aminophylline on hemodynamics and acid-base and blood gas balances were evaluated by 11 infusions to four chronically catheterized sheep at 114-142 days' gestation. Maternal and fetal arterial blood samples were drawn for baseline determination at 15-minute intervals. Mean maternal and fetal pH levels and heart rates increased significantly. Respiratory alkalosis was indicated by a concomitant fall in mean maternal carbon dioxide pressure. We conclude that aminophylline infusion (5.6 mg/kg of body weight/15 min) to pregnant sheep may cause maternal and fetal tachycardia and alkalosis, with a possible increase in uterine blood flow, but no changes in fetal blood gas status or blood pressure.

• Authors: J Ayromlooi, M Tobias, D Desiderio
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 18 Issue 3 Pg. 218-23 ( 1980) ISSN: 0020-7292 [Print] United States
• PMID: 6109660 (Publication Type: Journal Article)

Chemical References

• Carbon Dioxide
• Aminophylline
• Oxygen

Topics

• Acid-Base Equilibrium (drug effects)
• Aminophylline (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Carbon Dioxide (blood)
• Female
• Fetus (drug effects)
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Oxygen (blood)
• Pregnancy
• Regional Blood Flow (drug effects)
• Sheep
• Uterus (blood supply)