HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Haemodynamics of hypertension in pregnancy assessed by M-mode echocardiography.

Abstract
1. Echocardiographic haemodynamic and left ventricular parameters were determined in twenty-one normontensives and thirty-six hypertensives during the last trimester of pregnancy. 2. Equivalent blood pressure control was obtained in hypertensives with bet rest only, oxprenolol or methyldopa, but remained above normotensive levels. 3. Cardiac output was elevated in the last trimester of pregnancy in normotensivves and hypertensives. 4. Left ventricular mass was increased in normal pregnancy, but displayed an exaggerated increase in hypertensives. 5. Total peripheral resistance was inappropriately elevated in hypertensive pregnancy, but was normalized in the oxprenolol-treated group. 6. There was no reduction in heart rate or cardiac output in the beta-adrenoreceptor blocker-treated group. This feature, in combination with lowered peripheral resistance, may contribute to the improvement in foetal outcome observed in maternal hypertension of pregnancy treated with oxprenolol.
AuthorsH Larkin, E D Gallery, S N Hunyor, A Z Gyory, E S Boyce
JournalClinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) 1980 Sep-Oct Vol. 7 Issue 5 Pg. 463-8 ISSN: 0305-1870 [Print] Australia
PMID6108809 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
Topics
  • Adrenergic beta-Antagonists (pharmacology)
  • Adult
  • Blood Pressure
  • Cardiac Output
  • Echocardiography
  • Female
  • Hemodynamics
  • Humans
  • Hypertension (physiopathology)
  • Pregnancy
  • Pregnancy Complications, Cardiovascular (physiopathology)
  • Vascular Resistance

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: