HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Oral versus intramuscular vitamin A in the treatment of xerophthalmia.

Abstract
In a controlled trial 69 children with corneal xerophthalmia were given 200 000 IU oil-miscible vitamin A by mouth and a matched group of 45 children were given 100 000 IU water-miscible vitamin A intramuscularly. Both groups received an additional oral dose the next day. There was no detectable difference in the clinical response to the two regimes, even when analysis was limited to patients with concomitant diarrhoea or protein-energy malnutrition. Although serum-vitamin-A levels were significantly higher after parenteral than oral therapy, holoretinol-binding-protein levels were not. Oral administration of vitamin A is not only more practical but appears to be just as effective as parenteral administration in the treatment of severe xerophthalmia.
AuthorsA Sommer, Muhilal, I Tarwotjo, E Djunaedi, J Glover
JournalLancet (London, England) (Lancet) Vol. 1 Issue 8168 Pt 1 Pg. 557-9 (Mar 15 1980) ISSN: 0140-6736 [Print] England
PMID6102284 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Vitamin A
Topics
  • Administration, Oral
  • Child
  • Child, Preschool
  • Diarrhea, Infantile (metabolism)
  • Humans
  • Infant
  • Injections, Intramuscular
  • Intestinal Absorption
  • Protein-Energy Malnutrition (metabolism)
  • Vitamin A (administration & dosage, blood)
  • Xerophthalmia (blood, drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: