[Pregnancy-specific beta-1 glycoprotein (SP1) as a marker for tumors with or without trophoblastic character].

Abstract

The pregnancy specific beta-1-glycoprotein (SP1) was measured by radioimmunoassay in 854 persons (control group 103, non-tumoral diseases 212, germinal tumors 30, and non-germinal tumors 509). Amounts higher than 2.5 ng/ml (upper normal limit) were observed in 35 cases with non tumoral diseases (specially chronic liver diseases), 97 of the non-germinal tumors (specially mammary, respiratory and digestive tumors), and 10 of the germinal tumors (pure and mixed choriocarcinomas, and embryonic carcinoma with yolk sac component). SP1 rarely is higher than 5 ng/ml in non-tumoral diseases and non-germinal tumors, while it is higher than 5 ng/ml in germinal tumors. SP1 is a good marker for trophoblastic neoplasms and shows a correlation with HCG-beta.

• Authors: A Ruibal, R Comet, F J Alvarez Moro, A Lafuerza, F M Domenech-Torné, L Salvador
• Journal: Revista espanola de oncologia (Rev Esp Oncol) Vol. 31 Issue 3 Pg. 427-34 ( 1984) ISSN: 0482-640X [Print] Spain
• Vernacular Title: La beta-1 glicoproteina específica del embarazo (SP1) como marcador de los tumores de naturaleza trofoblástica o no.
• PMID: 6100801 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neoplasm Proteins
• Pregnancy Proteins
• Pregnancy-Specific beta 1-Glycoproteins

Topics

• Age Factors
• Disease (blood)
• Female
• Humans
• Neoplasm Proteins (blood)
• Neoplasms (blood)
• Pregnancy
• Pregnancy Proteins (blood)
• Pregnancy-Specific beta 1-Glycoproteins (blood)
• Trophoblastic Neoplasms (blood, diagnosis)
• Uterine Neoplasms (blood)