Abstract |
Sulbactam/ cefoperazone (SBT/CPZ) was evaluated in the treatment of pediatric patients to have the following results: Peak serum concentrations which occurred just after the drip infusion of 20 mg/kg SBT/CPZ were 36.4 micrograms/ml and 8.6 micrograms/ml for CPZ and SBT, respectively. The half-life of CPZ was 1.91 hours, and that of SBT, 0.97 hour. Following the 40 mg/kg drip infusion, the peak serum concentration of CPZ was 79.1 micrograms/ml, and that of SBT, 27.0 micrograms/ml. The half-lives were 1.99 hours for CPZ, and 1.07 hours for SBT, respectively. In 6 hours after drip infusion of 20 mg/kg and 40 mg/kg 21.7, 37.0% of CPZ and 41.6, 85.6% of SBT were excreted in urine. Daily doses of about 50-90 mg/kg SBT/CPZ were administered by intravenous or drip infusion to 26 pediatric patients with acute infections such as lacunar tonsillitis, bronchitis, bronchopneumonia, suppurative diseases caused by Staphylococcus ( staphylococcal scalded skin syndrome), purulent parotitis, cervical lymphadenitis, phlegmon and acute UTI related with ABPC/CPZ resistant beta lactamase producing E. coli. SBT/CPZ demonstrated the bacteriological effect on all the causative organisms. The clinical efficacy was also confirmed with the efficacy rate of 88.5%. No side effects were observed in all the cases though transient eosinophilia developed in 2 patients.
|
Authors | S Nakazawa, H Sato, A Narita, S Nakazawa, H Suzuki, H Chikaoka, K Tazoe |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 37
Issue 11
Pg. 2174-87
(Nov 1984)
ISSN: 0368-2781 [Print] Japan |
PMID | 6098710
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Drug Combinations
- beta-Lactamase Inhibitors
- Cefoperazone
- Penicillanic Acid
- Sulbactam
|
Topics |
- Adolescent
- Bacteria
(drug effects, enzymology)
- Bacterial Infections
(drug therapy)
- Cefoperazone
(administration & dosage, metabolism, pharmacology)
- Child
- Child, Preschool
- Drug Combinations
- Drug Evaluation
- Drug Resistance, Microbial
- Female
- Humans
- Injections, Intravenous
- Male
- Penicillanic Acid
(administration & dosage, metabolism, pharmacology)
- Sulbactam
- beta-Lactamase Inhibitors
|