HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chronic murine paracoccidioidomycosis: effect of ketoconazole on clearance of Paracoccidioides brasiliensis and immune response.

Abstract
In a murine model of chronic pulmonary and disseminated paracoccidioidomycosis, ketoconazole (100 mg kg-1 in 0.3% agar) given by gavage twice daily for 1 or 2 months enabled all mice to clear disseminated Paracoccidioides brasiliensis from the spleen. Clearance of P. brasiliensis from the lungs was more difficult, and was achieved in 60% of the mice treated for 2 months. Sera from agar-treated control mice at days 77 and 103 post-infection demonstrated precipitating antibodies to P. brasiliensis antigens, but sera from ketoconazole-treated mice were precipitin-negative, indicating a favorable prognosis. Delayed hypersensitivity reactions to P. brasiliensis antigens in ketoconazole-treated mice were not significantly greater than in controls; consequently this test correlated less well with response than levels of serum antibody. This is the first use of this animal model of paracoccidioidomycosis to study the effect of antifungal drug protocols on the resolution of the disease. It also demonstrates the utility of this model in addressing clinically relevant questions about this disease and its treatment.
AuthorsG L Hoyos, J G McEwen, E Brummer, E Castañeda, A Restrepo, D A Stevens
JournalSabouraudia (Sabouraudia) Vol. 22 Issue 5 Pg. 419-26 ( 1984) ISSN: 0036-2174 [Print] England
PMID6095472 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Antibodies, Fungal
  • Ketoconazole
Topics
  • Animals
  • Antibodies, Fungal (biosynthesis)
  • Chronic Disease
  • Disease Models, Animal
  • Fungi (drug effects)
  • Hypersensitivity, Delayed (immunology)
  • Ketoconazole (pharmacology)
  • Lung Diseases, Fungal (drug therapy, immunology, microbiology)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Paracoccidioides (drug effects, immunology, isolation & purification)
  • Paracoccidioidomycosis (drug therapy, immunology, microbiology)
  • Spleen (microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: