Activity of human recombinant and lymphoblastoid interferons in human and heterologous cell lines.

Abstract

Three human alpha interferon (HuIFN-alpha) preparations currently being used in clinical trials, rIFN-alpha A, rIFN-alpha 2, and lymphoblastoid IFN (LYM-IFN) had appreciable activity against encephalomyocarditis and vesicular stomatitis viruses (VSV) in guinea pig transformed and guinea pig embryo cells, but not mouse L or rabbit kidney cells. The level of activity in guinea pig cells, compared with human WISH cells, was 182% (range 9%-1,900%). These results suggest that the guinea pig may be useful for testing the antiviral, anticancer, or immunomodulatory activity of Hu alpha IFNs in vivo.

• Authors: J C Overall Jr, T J Yeh, E R Kern
• Journal: Journal of interferon research (J Interferon Res) Vol. 4 Issue 4 Pg. 529-33 ( 1984) ISSN: 0197-8357 [Print] United States
• PMID: 6094683 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Interferon Type I

Topics

• Animals
• Cell Line
• Cell Transformation, Viral
• Encephalomyocarditis virus (drug effects)
• Guinea Pigs
• Humans
• Interferon Type I (pharmacology)
• Mice
• Rabbits
• Species Specificity
• Vesicular stomatitis Indiana virus (drug effects)