Chronic anemia progressing to Auer rod-positive and TdT-positive acute leukemia with 5q- chromosomal anomaly.

Abstract

The 5q- syndrome is a recently described entity characterized by partial deletion of the long arm of chromosome No. 5 and by hematologic findings of chronic anemia with reticulocytopenia, nonlobulated megakaryocytes, and megathrombocytes. We report on a patient with the hematologic features of the 5q- syndrome who progressed to acute leukemia and whose uniqueness consisted of 1) lack of additional cytogenetic abnormalities, 2) presence of blasts with Auer rods, and 3) bone marrow cells positive for terminal deoxynucleotidyl transferase. His leukemia was refractory to conventional chemotherapy.

• Authors: A M Xavier, B S Kasimis
• Journal: American journal of hematology (Am J Hematol) Vol. 17 Issue 4 Pg. 409-16 ( 1984) ISSN: 0361-8609 [Print] United States
• PMID: 6093506 (Publication Type: Case Reports, Journal Article)

Chemical References

• DNA Nucleotidyltransferases
• DNA Nucleotidylexotransferase

Topics

• Acute Disease
• Anemia (blood)
• Cell Transformation, Neoplastic (pathology)
• Chromosome Aberrations (blood, pathology)
• Chromosome Disorders
• Chromosomes, Human, 4-5
• DNA Nucleotidylexotransferase (blood)
• DNA Nucleotidyltransferases (blood)
• Humans
• Inclusion Bodies (pathology)
• Leukemia (blood, drug therapy, pathology)
• Male
• Middle Aged
• Syndrome