Abstract |
The monoamine oxidase activity in the cerebral hemispheres decreased significantly after 2, 4, 8 and 16 hr of 6-amino-nicotinamide (35 mg/kg body weight, i.p.) administration. In the cerebellum, the MAO activity was not affected significantly. In the brain stem, however, a significant increase was observed after 2 hr of drug administration followed by a gradual decrease at later time intervals. The Na+K+ ATPase activity in the cerebral hemispheres was increased significantly at 2 and 4 hr of 6-aminonicotinamide administration. This was followed by a gradual decrease at later time intervals. In the cerebellum, like monoamine oxidase, the Na+K+ ATPase did not change significantly. The brain stem showed a decrease at 2 hr of drug administration, followed by a significant increase at 4 hr and then a gradual decrease to near control values.
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Authors | C K Mayanil, S M Kazmi, N Z Baquer |
Journal | Biochemical pharmacology
(Biochem Pharmacol)
Vol. 33
Issue 19
Pg. 3021-3
(Oct 01 1984)
ISSN: 0006-2952 [Print] England |
PMID | 6091665
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Niacinamide
- 6-Aminonicotinamide
- Adenosine Triphosphate
- Monoamine Oxidase
- Sodium-Potassium-Exchanging ATPase
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Topics |
- 6-Aminonicotinamide
(pharmacology)
- Adenosine Triphosphate
(analysis)
- Animals
- Brain
(drug effects, enzymology)
- Monoamine Oxidase
(analysis)
- Niacinamide
(analogs & derivatives)
- Rats
- Rats, Inbred Strains
- Sodium-Potassium-Exchanging ATPase
(analysis)
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