Abstract |
The response to exogenous parathyroid hormone (PTH) with urinary excretion of phosphate and cyclic adenosine monophosphate (cAMP) was tested by the use of synthetic human parathyroid hormone (1-34) [ hPTH-(1-34)] on 59 patients with hypocalcemia and normal or high serum inorganic phosphorus and normal renal function without a history of parathyroidectomy for differentiation between idiopathic hypoparathyroidism (IHP), pseudohypoparathyroidism (PHP) and related diseases along with 18 normal subjects. A positive phosphaturic response to exogenous PTH was defined as the increment of 2 hours phosphate excretion (delta P) of more than 35 mg. A positive urinary cAMP response to exogenous PTH was defined as the increment by more than 1 mumole per one hour (delta cAMP) and the increase of 1 hour excretion by more than 10 times. Increments of 2 hours urinary phosphate excretion in response to hPTH-(1-34) 100 units were 60.5 +/- 7.7 mg (mean +/- SEM) in 27 patients with IHP, 23.5 +/- 5.9 mg in 21 patients with PHP type I and 24.9 +/- 4.0 mg in 17 normal subjects. Increments of 1 hour urinary cAMP excretion in response to hPTH-(1-34) 100 units were 12.0 +/- 1.5 mumole in 27 patients with IHP, 0.33 +/- 0.10 mumole in patients with PHP type I and 23.6 +/- 5.8 mumole in 15 normal subjects. Ratios of 1 hour urinary cAMP excretion were 97 +/- 10 in 27 patients with IHP, 3.6 +/- 0.5 in 21 patients with PHP type I and 54 +/- 14 in 15 normal subjects. Positive phosphaturic and negative urinary cAMP response was encountered in 3 out of 21 patients with PHP type I in response to hPTH-(1-34). This exaggerated phosphaturic response should be considered as due to the influence of treatment with Ca or vitamin D derivatives.
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Authors | T Fukami, T Fujita, Y Yoshimoto, M Fukase, Y Imai, K Sakaguchi, E Ogata, Y Furukawa, H Suzuki, K Takebe |
Journal | Nihon Naibunpi Gakkai zasshi
(Nihon Naibunpi Gakkai Zasshi)
Vol. 60
Issue 3
Pg. 159-70
(Mar 20 1984)
ISSN: 0029-0661 [Print] Japan |
PMID | 6090236
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Hormones
- Parathyroid Hormone
- Peptide Fragments
- Phosphates
- Teriparatide
- Cyclic AMP
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Topics |
- Adolescent
- Adult
- Aged
- Cyclic AMP
(urine)
- Diagnosis, Differential
- Female
- Hormones
- Humans
- Hypoparathyroidism
(diagnosis)
- Male
- Middle Aged
- Parathyroid Hormone
- Peptide Fragments
- Phosphates
(urine)
- Pseudohypoparathyroidism
(diagnosis)
- Pseudopseudohypoparathyroidism
(diagnosis)
- Teriparatide
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