[Effect of various vasoactive drugs on synaptic transmission in the orthosympathetic ganglia in man].

Abstract

The effects of the following vasoactive drugs: Bencyclan fumarate, Cetiedil citrate, Cinepazide maleate, Dihydroergocristine methane sulphonate, Nafthydrofuril acid oxalate, Papaverine hydrochloride, Piribedil monomethane sulphonate, Raubasine, Thymoxamine hydrochloride and Xanthinol nicotinate, in concentrations ranging between 0.001 - 2 mM, were tested on the compound action potentials led off from human isolated sympathetic ganglions. The experiments, carried out on 50 isolated lumbar ganglion preparations removed from 23 subjects with arteriopathy of the limbs, indicated that all the drugs are able to impair the synaptic transmission, although at different concentrations. These findings are in favour of the hypothesis that the vasodilatatory effects observed after therapeutic treatment of patients with vasoactive drugs are partially produced by the vasodilatation following the depression of the sympathetic nervous transmission.

• Authors: P Valli, G Zucca, R Seghezzi, L Botta
• Journal: Bollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) Vol. 60 Issue 6 Pg. 1191-7 (Jun 30 1984) ISSN: 0037-8771 [Print] Italy
• Vernacular Title: Influenza di alcuni farmaci vasoattivi sulla trasmissione sinaptica in gangli ortosimpatici umani.
• PMID: 6089853 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Vasodilator Agents

Topics

• Action Potentials (drug effects)
• Animals
• Electric Stimulation
• Ganglia, Sympathetic (drug effects)
• Humans
• In Vitro Techniques
• Rats
• Rats, Inbred Strains
• Synaptic Transmission (drug effects)
• Vasodilator Agents (pharmacology)