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Reevaluation of 5-fluorouracil as a single therapeutic agent for gestational trophoblastic neoplasms.

Abstract
Large dosage of 5-fluorouracil given by slow intravenous infusion has proved to be very effective in the treatment of gestational trophoblastic neoplasms. From 1965 through 1975, 5-fluorouracil was used as a single chemotherapeutic agent in 173 cases of invasive mole and 139 cases of choriocarcinoma. Complete remission was achieved in 84.9% of cases of invasive mole and in 59.3% of cases of choriocarcinoma when 5-fluorouracil was used as the initial treatment. Seven recurrences with three deaths occurred during follow-up in 216 patients who had achieved complete remission, providing a recurrence rate of 3.2% and recurrence death rate of 1.4%. All of the survivors were followed up for more than 5 years and 85.6% for more than 10 years. Toxicity of 5-fluorouracil was milder and less frequent than that of 6-mercaptopurine or methotrexate. The toxic reaction specific to 5-fluorouracil was diarrhea, which can result in pseudomembranous colitis if improperly treated. One of the two toxic deaths was due to this complication.
AuthorsH C Sung, P C Wu, H Y Yang
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 150 Issue 1 Pg. 69-75 (Sep 01 1984) ISSN: 0002-9378 [Print] United States
PMID6089563 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Mercaptopurine
  • Fluorouracil
  • Methotrexate
Topics
  • Choriocarcinoma (drug therapy, mortality)
  • Diarrhea (chemically induced)
  • Female
  • Fluorouracil (adverse effects, therapeutic use)
  • Follow-Up Studies
  • Humans
  • Hydatidiform Mole, Invasive (drug therapy, mortality)
  • Mercaptopurine (therapeutic use)
  • Methotrexate (therapeutic use)
  • Neoplasm Recurrence, Local (drug therapy)
  • Pregnancy
  • Uterine Neoplasms (drug therapy, mortality)

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