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Biliary excretion of ceftizoxime in humans.

Abstract
Biliary concentrations of a new cephalosporin, ceftizoxime, were measured in bile collected in 8 cholecystectomized patients provided with T-tube drainage and in 14 patients where bile was obtained by puncture of the gall bladder and choledochus during cholecystectomy. In patients with external biliary drainage, a mean biliary peak of 150.3 +/- SEM 49.8 micrograms/ml has been observed 2 h after intravenous injection of 2 g of ceftizoxime; the antibiotic activity amounted still to 17.3 +/- 6.0 micrograms/ml after 6 h. Assays performed during operation showed the following simultaneous concentrations 1 h after 2 g of ceftizoxime given intravenously: serum: 85.3 +/- 8.1 micrograms/ml; main duct bile: 279.8 +/- 40.0 micrograms/ml; gallbladder bile: 119.9 +/- 19.4 micrograms/ml. These findings were compared with the biliary excretion of 8 other cephalosporins studied previously under the same conditions. The results of the present study suggest that administration of ceftizoxime may be effective in the treatment of biliary tract infections.
AuthorsJ M Brogard, J P Arnaud, R Timmler
JournalChemotherapy (Chemotherapy) Vol. 30 Issue 4 Pg. 221-6 ( 1984) ISSN: 0009-3157 [Print] Switzerland
PMID6086245 (Publication Type: Journal Article)
Chemical References
  • Ceftizoxime
  • Cefotaxime
Topics
  • Bile (metabolism)
  • Biliary Tract Surgical Procedures
  • Cefotaxime (analogs & derivatives, metabolism)
  • Ceftizoxime
  • Cholecystectomy
  • Common Bile Duct (metabolism)
  • Drainage
  • Gallbladder (metabolism)
  • Humans
  • Injections, Intravenous
  • Kinetics

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