Abstract |
Biliary concentrations of a new cephalosporin, ceftizoxime, were measured in bile collected in 8 cholecystectomized patients provided with T-tube drainage and in 14 patients where bile was obtained by puncture of the gall bladder and choledochus during cholecystectomy. In patients with external biliary drainage, a mean biliary peak of 150.3 +/- SEM 49.8 micrograms/ml has been observed 2 h after intravenous injection of 2 g of ceftizoxime; the antibiotic activity amounted still to 17.3 +/- 6.0 micrograms/ml after 6 h. Assays performed during operation showed the following simultaneous concentrations 1 h after 2 g of ceftizoxime given intravenously: serum: 85.3 +/- 8.1 micrograms/ml; main duct bile: 279.8 +/- 40.0 micrograms/ml; gallbladder bile: 119.9 +/- 19.4 micrograms/ml. These findings were compared with the biliary excretion of 8 other cephalosporins studied previously under the same conditions. The results of the present study suggest that administration of ceftizoxime may be effective in the treatment of biliary tract infections.
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Authors | J M Brogard, J P Arnaud, R Timmler |
Journal | Chemotherapy
(Chemotherapy)
Vol. 30
Issue 4
Pg. 221-6
( 1984)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 6086245
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Bile
(metabolism)
- Biliary Tract Surgical Procedures
- Cefotaxime
(analogs & derivatives, metabolism)
- Ceftizoxime
- Cholecystectomy
- Common Bile Duct
(metabolism)
- Drainage
- Gallbladder
(metabolism)
- Humans
- Injections, Intravenous
- Kinetics
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