Abstract |
Three patients, a mother and her two sons, with mutilating palmoplantar keratoderma (Vohwinkel's syndrome) were successfully treated with oral etretinate ( Tigason). All of them had keratotic constriction furrows of one or more digits (pseudo- ainhum) with threatening spontaneous amputation. Oral treatment with etretinate brought about disappearance of the pseudo-ainhums and normalization of the digital blood circulation. The hyperkeratotic skin became thinned and pliable with a dose-dependent trend towards redness and atrophy. Continued long term etretinate medication has made it possible for these patients to fulfill their social and occupational activities. All 3 patients had acoustic impairment of high-pitched tone perception.
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Authors | K Wereide |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 64
Issue 6
Pg. 566-9
( 1984)
ISSN: 0001-5555 [Print] Sweden |
PMID | 6084939
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Etretinate
(therapeutic use)
- Female
- Fingers
(pathology)
- Hearing Loss, High-Frequency
(etiology)
- Humans
- Keratoderma, Palmoplantar
(drug therapy, genetics, pathology)
- Male
- Middle Aged
- Skin
(pathology)
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