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Influence of dietary protein level on protein self-selection and plasma and brain amino acid concentrations.

Abstract
Control of protein intake was studied in young rats that were allowed to choose between either protein-free and 55% casein diets or 15% and 55% casein diets. Animals on the protein-free vs. 55% casein regimen exhibited a lower weight gain, a lower cumulative energy intake and a greater cumulative total protein intake during the 13-day study compared to rats selecting between 15% and 55% casein. The daily average proportion of total food selected as casein by animals choosing between protein-free and 55% casein diets increased from 15% to 38% during the course of the study. In contrast, rats choosing between 15% and 55% casein chose 18-22% of total food as protein throughout the entire study. Long-term protein intake or protein selection did not correlate significantly with whole-brain contents of 5-HT or 5-HIAA. Our results suggest that protein intake is not regulated at a constant proportion of total calories, but is controlled between a minimum level that will support rapid growth and a maximum that, if exceeded, would require the animal to undergo substantial metabolic adaptation. The mechanism controlling protein selection may involve diet-induced changes in the brain content of total free indispensable amino acids.
AuthorsJ C Peters, A E Harper
JournalPhysiology & behavior (Physiol Behav) Vol. 33 Issue 5 Pg. 783-90 (Nov 1984) ISSN: 0031-9384 [Print] United States
PMID6084254 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amino Acids
  • Caseins
  • Dietary Proteins
  • Serotonin
  • Hydroxyindoleacetic Acid
Topics
  • Amino Acids (analysis, blood)
  • Animals
  • Brain Chemistry
  • Caseins (administration & dosage)
  • Dietary Proteins (administration & dosage)
  • Food Preferences
  • Growth
  • Hydroxyindoleacetic Acid (analysis)
  • Male
  • Rats
  • Serotonin (analysis)

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