The average plasma
testosterone concentration of women with either
hirsutism or polycystic ovaries and
hirsutism was higher (p < 0.01) than that of normal women although the ranges overlapped.
Testosterone blood production rates averaged 830 +/- 120 SE and 1,180 +/- 310 SE mug per day in the two groups of hirsute women and 230 +/- 33 SE mug per day in normal women. The ranges did not overlap. The
testosterone metabolic clearance rates of hirsute women (1,090 +/- 140 SE L per day) and of men (1,240 +/- 136 SE L per day) were significantly higher than those of normal women (590 +/- 44 SE L per day). These differences persisted when the metabolic clearance rates were corrected for surface area. We suggest that
testosterone metabolic clearance rates vary directly with some function of
testosterone production. The mean plasma
androstenedione levels (2.8 +/- 0.35 SE and 2.8 +/- 0.30 SE mug per L) and production rates (6,060 +/- 450 SE and 7,360 +/- 345 SE mug per day) of the women with
hirsutism or polycystic ovaries, respectively, were significantly higher than those of normal women (1.5 +/- 0.22 SE mug per L; 3,300 +/- 830 SE mug per day). The
androstenedione metabolic clearance rates were the same in each group. Plasma
androstenedione was the precursor of 49% of plasma
testosterone in normal women and of 26% of plasma
testosterone in hirsute women. Thus, 74% of the plasma
testosterone in these subjects must have been either secreted or derived from a precursor that did not enter the plasma
androstenedione pool.