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Effects of alpha-adrenergic blockade on coronary blood flow of dogs in hemorrhagic shock.

Abstract
The present study was designed to test the hypothesis that the vasoconstrictive effects of alpha-adrenergic receptors are responsible, at least in part, for the lack of a maximal vasodilatation of coronary arteries during hemorrhagic shock. Open-chested, anesthetized, mongrel dogs were bled so as to reach an arterial pressure level of 44 mm Hg, and were monitored using an electromagnetic, non-cannulating flowmeter. During shock, two intracoronary injections were made, one of saline, the other of phenoxybenzamine (Dibenzyline). Control dogs had 2 injections of saline. Following phenoxybenzamine, coronary blood flow increased by 32%. These results indicate that although coronary blood flow may be mainly under local control, the sympathetic nervous system limits maximal coronary vasodilatation during hemorrhagic shock by virtue of activated alpha-adrenergic receptors.
AuthorsF Birinyi, D B Hackel, E Mikat
JournalCirculatory shock (Circ Shock) Vol. 4 Issue 4 Pg. 297-303 ( 1977) ISSN: 0092-6213 [Print] United States
PMID598003 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Phenoxybenzamine
  • Sodium Chloride
Topics
  • Animals
  • Blood Flow Velocity
  • Coronary Circulation (drug effects)
  • Dogs
  • Male
  • Phenoxybenzamine (administration & dosage, pharmacology)
  • Shock, Hemorrhagic (physiopathology)
  • Sodium Chloride (administration & dosage)

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