Urinary ammonia and ammonia-producing microorganisms in infants with and without diaper dermatitis.

Abstract

Free ammonia was determined in diaper squeezings from 26 infants with "ammoniacal dermatitis" and in 82 controls. No significant difference was found (402 ppm in diaper dermatitis compared to 465 in controls). The groups did not differ with regard to the incidence of organisms capable of splitting ammonia from urea. Experimental application of highly ammoniacal urine on intact infant and adult skin failed to provoke a dermatitis. Erythema could be induced only when ammoniacal urine was applied occlusively to scarified skin. These findings do not support the notion that ammonia is a primary factor in common diaper rash, but do not exclude a possible role for further irritation in an already existent condition.

• Authors: J J Leyden, S Katz, R Stewart, A M Kligman
• Journal: Archives of dermatology (Arch Dermatol) Vol. 113 Issue 12 Pg. 1678-80 (Dec 1977) ISSN: 0003-987X [Print] United States
• PMID: 596897 (Publication Type: Journal Article)

Chemical References

• Ammonia
• Urea

Topics

• Ammonia (adverse effects, metabolism, urine)
• Bacteria (metabolism)
• Brevibacterium (metabolism)
• Child, Preschool
• Diaper Rash (chemically induced, etiology, microbiology)
• Erythema (chemically induced)
• Humans
• Infant
• Skin (drug effects)
• Urea (metabolism)