Abstract |
The effect of dehydration on intrarenal blood flow was investigated in 11 dogs, using polarographic determination of H2-gas desaturation for measuring local blood flow in inner cortex (ICF) and outer cortex (OCF). Dehydration was induced by 48 h water deprivation +2-300 mg ethacrynic acid (EA) per os the day before the experiment. Compared to a control group (n=9) ICF was markedly reduced to 2.40 +/- 0.47 ml/min X g (control 3.23 +/- 0.64) whereas OCF 3.29 +/- 0.80 ml/min X g was nearly unchanged (control 3.59 +/- 0.85). The ratio OCF/ICF was increased to 1.37 (1.11). Further dehydration by hypertonic peritoneal dialysis for 3 h increased Hct to 60 +/- 4 and further reduced OCF and ICF, without significant change of the OCF/ICF-ratio. At Hct above 55 sudden and intermittent changes in local cortical blood flow were recorded randomly at individual electrode sites, showing ischemic periods lasting for 1 to 60 min. Such flow changes were observed in 13 of 14 expts. and were not accompanied by changes in RBF. It is concluded that moderate dehydration causes a greater reduction of ICF than of OCF. Severe dehydration gives in addition rise to patchy, intermittent ischemia in both cortical layers.
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Authors | A Kirkebo, I Tyssebotn |
Journal | Acta physiologica Scandinavica
(Acta Physiol Scand)
Vol. 101
Issue 3
Pg. 257-63
(Nov 1977)
ISSN: 0001-6772 [Print] England |
PMID | 596201
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Dehydration
(complications, etiology, physiopathology)
- Dogs
- Ethacrynic Acid
- Ischemia
(etiology)
- Kidney Cortex
(blood supply)
- Peritoneal Dialysis
- Regional Blood Flow
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