[Clinical and experimental studies on the efficiency of nifedipine on smooth muscle strips of the esophagus (author's transl)].

Abstract

Based on in vivo studies on isolated muscle strips of the LES and on manometric in vivo studies on 8 mongrel dogs, 6 healthy volunteers, 6 patients with achalasia and 3 subjects with diffuse esophageal spasm we could demonstrate that nifedipine causes a long-lasting relaxation of smooth muscle, the esophagus and LES. In 8 dogs resting pressure at the LES was decreased by 20 mg nifedipine from 18.5 +/- 1.8 mm Hg to 8.2 +/- 0.9 mm Hg. This pressure decrease could not be reversed by pentagastrin stimulation (3.0 microgram/kg KG PG). The resting pressure in LES was decreased from 26.8 +/- 3.8 mm Hg to 16.4 +/- 2.1 mm Hg in healthy volunteers and from 45.5 +/- 2.6 mm Hg to 14.5 +/- 0.4 mm Hg in patients with achalasia. In 3 patients with diffuse esophageal spasm nifedipine (20 mg) caused a mean decrease of 38% of the contraction amplitude. Further clinical studies have to be done to clarify if the spasmolysis by nifedipine may be important in the treatment of spastic or hypertonic motility disorders of the LES and the esophagus.

• Authors: H F Weiser, G Lepsien, K Golenhofen, G Schattenmann, R Siewert
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 15 Issue 11 Pg. 691-8 (Nov 1977) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Klinische und experimentelle Untersuchungen zur Wirkung von Nifedipine auf die glatte Muskulatur des Osophagus.
• PMID: 595746 (Publication Type: English Abstract, Journal Article)

Chemical References

• Pyridines
• Nifedipine

Topics

• Adult
• Animals
• Dogs
• Dose-Response Relationship, Drug
• Esophageal Achalasia (physiopathology)
• Esophagus (physiology, physiopathology)
• Female
• Humans
• Male
• Muscle Contraction (drug effects)
• Nifedipine (pharmacology)
• Pyridines
• Spasm (physiopathology)