Severe depressive mood changes following slow-release intramuscular fluphenazine injection.

Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection. In five cases this depression is thought to have been responsible for suicide. In 8 out of 10 cases the depression responded to electroplexy (E.C.T.). It is recommended that patients who are treated with fluphenazine should be carefully supervised.
AuthorsR De Alarcon, M W Carney
JournalBritish medical journal (Br Med J) Vol. 3 Issue 5670 Pg. 564-7 (Sep 06 1969) ISSN: 0007-1447 [Print] England
PMID5808010 (Publication Type: Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Fluphenazine
  • Adult
  • Delayed-Action Preparations
  • Depression (chemically induced)
  • Electroconvulsive Therapy
  • Female
  • Fluphenazine (adverse effects)
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Schizophrenia (drug therapy)
  • Suicide

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