Fat cell size and lipid content of subcutaneous tissue in congenital generalized lipodystrophy.

Abstract

Fat cell size and lipid composition of subcutaneous tissue from 3 patients with congenital generalized lipodystrophy have been measured before and after treatment with either pimozide, fenfluramine or hypophysectomy. The fat cell volume before treatment ranged between 9.8 x 10(4) and 17.7 x 10(4) micron 3, compared to 9.0 x 10(4) and 85.3 x 10(4) micron 3 in 15 controls. The amount of lipids was only 1/10 to 1/50 of normal, triglycerides being the most heavily reduced lipid component. Neither the fat cell size nor the lipid content were affected by treatment with hypophysectomy, pimozide or fenfluramine.

• Authors: T O Rognum, K S Bjerve, M Seip, O Trygstad, S Oseid
• Journal: Acta endocrinologica (Acta Endocrinol (Copenh)) Vol. 88 Issue 1 Pg. 182-9 (May 1978) ISSN: 0001-5598 [Print] Denmark
• PMID: 580534 (Publication Type: Journal Article)

Chemical References

• Pimozide
• Fenfluramine

Topics

• Adipose Tissue (cytology, metabolism)
• Adult
• Child
• Female
• Fenfluramine (therapeutic use)
• Humans
• Hypophysectomy
• Lipid Metabolism
• Lipodystrophy (congenital, drug therapy, metabolism)
• Male
• Pimozide (therapeutic use)