Abstract |
Oral (PO) administration of KS-2 to adult DDI mice resulted in a peak serum interferon (IF) titer of 800 units (U)/ml 20 hours after administration with detectable levels persisting until 30 hours. After intraperitoneal (IP) injection, a peak serum IF titer of 1,600 U/ml was detected and it followed the same time course as that of oral administration. The IF induced by KS-2 shared certain physico-chemical properties with the standard preparation of immune IF and was not neutralized by an antiserum against type I IF. In mice infected intranasally (IN) with influenza A2 (H2N2) virus, KS-2 was found to possess significant protective activities. Efficacy of the agent was evidenced by an increase in survivor number, a prolongation of mean survival time, an inhibition of the development of lung consolidation induced by the viral infection and a decrease in virus titer in lung tissues. Both PO and IP administrations of KS-2 protected mice against infection and significant antiviral activities were achieved not only by prophylactic but also chemotherapeutic administration. The protective activities of KS-2 against influenza virus infection in mice are discussed in view of the immunopotentiation of the host animals.
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Authors | F Suzuki, C Suzuki, E Shimomura, H Maeda, T Fujii, N Ishida |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 32
Issue 12
Pg. 1336-45
(Dec 1979)
ISSN: 0021-8820 [Print] England |
PMID | 575532
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Glycopeptides
- Interferon Inducers
- Mannans
- Proteoglycans
- polysaccharide-K
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Topics |
- Agaricales
(metabolism)
- Animals
- Antiviral Agents
- Female
- Glycopeptides
(isolation & purification, pharmacology)
- Interferon Inducers
- Lung
(pathology)
- Male
- Mannans
(therapeutic use)
- Mice
- Mice, Inbred Strains
- Orthomyxoviridae Infections
(microbiology, pathology, prevention & control)
- Proteoglycans
- Time Factors
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