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Antiviral and interferon-inducing activities of a new peptidomannan, KS-2, extracted from culture mycelia of Lentinus edodes.

Abstract
Oral (PO) administration of KS-2 to adult DDI mice resulted in a peak serum interferon (IF) titer of 800 units (U)/ml 20 hours after administration with detectable levels persisting until 30 hours. After intraperitoneal (IP) injection, a peak serum IF titer of 1,600 U/ml was detected and it followed the same time course as that of oral administration. The IF induced by KS-2 shared certain physico-chemical properties with the standard preparation of immune IF and was not neutralized by an antiserum against type I IF. In mice infected intranasally (IN) with influenza A2 (H2N2) virus, KS-2 was found to possess significant protective activities. Efficacy of the agent was evidenced by an increase in survivor number, a prolongation of mean survival time, an inhibition of the development of lung consolidation induced by the viral infection and a decrease in virus titer in lung tissues. Both PO and IP administrations of KS-2 protected mice against infection and significant antiviral activities were achieved not only by prophylactic but also chemotherapeutic administration. The protective activities of KS-2 against influenza virus infection in mice are discussed in view of the immunopotentiation of the host animals.
AuthorsF Suzuki, C Suzuki, E Shimomura, H Maeda, T Fujii, N Ishida
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 32 Issue 12 Pg. 1336-45 (Dec 1979) ISSN: 0021-8820 [Print] England
PMID575532 (Publication Type: Journal Article)
Chemical References
  • Antiviral Agents
  • Glycopeptides
  • Interferon Inducers
  • Mannans
  • Proteoglycans
  • polysaccharide-K
Topics
  • Agaricales (metabolism)
  • Animals
  • Antiviral Agents
  • Female
  • Glycopeptides (isolation & purification, pharmacology)
  • Interferon Inducers
  • Lung (pathology)
  • Male
  • Mannans (therapeutic use)
  • Mice
  • Mice, Inbred Strains
  • Orthomyxoviridae Infections (microbiology, pathology, prevention & control)
  • Proteoglycans
  • Time Factors

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