[Effect of etimizol and sodium hydroxybutyrate on the compensatory-adaptive capabilities of newborns with chronic hypoxia].

Abstract

Daily injections of 5 mg/kg of aethimizol to female rabbits during the last week of pregnancy results in normalization of the central nervous and cardiovascular systems reactions in response to a graded mechanical stimulation, in an increased ATP content in the erythrocytes, lesser acidotonic shifts in the blood and marked diminution in the number of stillbirths. Under similar conditions of the exeriment sodium oxybutyrate in a dose of 200 mg/kg did not contribute to normalization of the central nervous and cardiovascular systems response reactions, nor did it lower the acidosis in the blood and had no marked effect on the reduction in the number of stillbirths.

• Authors: M L Tarakhovskiĭ, T D Zadorozhnaia, V K Tishchenko, A G Tsypkun
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1978 Nov-Dec Vol. 41 Issue 6 Pg. 686-90 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie étimizola i oksibutirata natriia na kompensatorno-prisposobitel'nye vozmozhnosti novorozhdennykh pri khronicheskoĭ gipoksii.
• PMID: 569076 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hydroxybutyrates
• Imidazoles
• Adenosine Diphosphate
• RNA
• Sodium Oxybate
• Adenosine Triphosphate
• Etimizol

Topics

• Adenosine Diphosphate (analysis)
• Adenosine Triphosphate (analysis)
• Animals
• Chronic Disease
• Erythrocytes (analysis)
• Etimizol (therapeutic use)
• Female
• Fetal Hypoxia (drug therapy, metabolism)
• Hydroxybutyrates (therapeutic use)
• Imidazoles (therapeutic use)
• Liver (analysis)
• Myocardium (analysis)
• Pregnancy
• RNA (analysis)
• Rabbits
• Sodium Oxybate (therapeutic use)