Levels of cellular DNA polymerases in synchronized bovine paravovirus-infected cells.

Abstract

Infection of synchronized bovine fetal spleen cells with bovine parvovirus results in changes in the levels and patterns of DNA polymerases alpha and gamma during the cell cycle. The pattern of DNA polymerase alpha activity closely paralled viral DNA synthesis and the production of progeny virus, and levels, of this enzyme were threefold greater than in mock-infected cells during the period of maximal viral DNA synthesis. DNA polymerase gamma activity remained slightly elevated during viral DNA replication. Levels and patterns of DNA polymerase beta were similar in mock- and virus-infected cells.

• Authors: C Pritchard, R C Bates, E R Stout
• Journal: Journal of virology (J Virol) Vol. 27 Issue 1 Pg. 258-61 (07 1978) ISSN: 0022-538X [Print] United States
• PMID: 567697 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Viral
• DNA
• DNA Polymerase I
• DNA Polymerase II
• DNA Polymerase III
• DNA-Directed DNA Polymerase

Topics

• Animals
• Cattle
• Cell Cycle
• Cells, Cultured
• DNA (biosynthesis)
• DNA Polymerase I (metabolism)
• DNA Polymerase II (metabolism)
• DNA Polymerase III (metabolism)
• DNA, Viral (biosynthesis)
• DNA-Directed DNA Polymerase (metabolism)
• Parvoviridae (growth & development)