The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.

Abstract

1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible mechanisms of action are discussed.

• Authors: J A Davies, J Williams
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 62 Issue 2 Pg. 303-5 (Feb 1978) ISSN: 0007-1188 [Print] England
• PMID: 564220 (Publication Type: Journal Article)

Chemical References

• Aminobutyrates
• Thioxanthenes
• Flupenthixol
• Baclofen

Topics

• Aminobutyrates (pharmacology)
• Animals
• Baclofen (pharmacology)
• Catalepsy (chemically induced, physiopathology)
• Drug Interactions
• Female
• Flupenthixol (pharmacology)
• Humans
• Rats
• Thioxanthenes (pharmacology)